CBD (Cannabidiol) oil is a product that’s extracted from cannabis. It’s a type of cannabinoid, which are chemicals naturally found in the cannabis Sativa plant. CBD has no psychoactive effect or any form of intoxication. There is now a growing awareness about the possible health benefits of CBD oil. Researchers strongly believe that CBD has the potential for medical use. CBD oil was researched countless times and its potential health benefits.

CBD Oil and Blood Pressure Medication Interaction

There is a vast range of prescribed medicine for lowering blood pressure, and it’s out of the question to speak in broad terms about how CBD oil interacts with all of them. Still, if you’re taking on of the more common prescriptions for hypertension (lisinopril, amlodipine besylate, hydrochlorothiazide, valsartan, or metoprolol beta-blocker), there are some things you should consider before using CBD oil.

CBD oil is publicly recognized as a safe compound with little to no known side effects. However, it has been suggested that CBD oil may affect the efficiency of blood pressure medication in controlling high blood pressure.

On the contrary, blood pressure medication is also believed to potentially reduce the effectiveness of CBD oil. Additionally, because CBD is an inhibitor of the cytochrome P-450 enzyme system, CBD oil should be used with utmost caution when combined with medications that use this pathway; for high blood pressure medications, metoprolol and amlodipine besylate specifically.

The cytochrome P-450 system contains liver enzymes that break down medications into smaller substances so that the body can efficiently process it. CBD and other natural substances like grapefruit slow down this pathway. This may cause high blood pressure medications that rely on the P-450 system to remain for longer periods in the system and increase the likelihood that you experience their adverse side effects.

With the possible side effects in mind, you may feel discouraged to try CBD oil while on high blood pressure medication. On the other hand, you may also consider using CBD oil on its own to manage your high blood pressure.

CBD oil has shown to reduce blood pressure by reducing stress, widening blood vessels, and by relieving anxiety. These benefits that CBD oil possesses encourage a lower heart rate, which ultimately reduces blood pressure.

CBD Oil and Blood Pressure Medication Together

It would be best if you began by consulting with your doctor. CBD oil can interact with your current high blood pressure medications, consulting with your doctor on the possible risks and benefits is crucial for your safety and health.

CBD products generally come with an information brochure that provides a recommended dosage. Still, you might want to consider starting with a lower amount than what is recommended and gradually increase the dosage over time as needed. This will allow your body to build a tolerance to CBD oil and reduce the risk of having a sudden drop in your blood pressure.

You may even find you are able to lower the dosage of your high blood pressure medication as the CBD oil becomes most effective.



1) Weinberger D. Dec 2019. CBD drug interactions: Is CBD safe to take with prescription medications? Available at :

2) N.A. N.D. Blood Pressure Medication and CBD Oil Interaction. Available at: